ZFIN Image: Korte et al., 2022, Figure 2

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Figure Caption

Figure 2

Thioredoxin expression is induced in neutrophils and keratinocytes with HRas^G12V transformation. (A) Volcano plots displaying number of significantly (adjusted p<0.05) downregulated and upregulated genes in keratinocytes and neutrophils in HRas^G12V-keratinocyte expressing zebrafish larvae, compared to wild-type HRas controls. (B) Gene Set Enrichment Analysis (GSEA) of significantly enriched Hallmark pathways in neutrophils and keratinocytes for HRas^G12V-keratinocyte expressing zebrafish. FDR q-value is (a) below 0.10 or (b) 0.10-0.25. (C) Heat maps displaying significantly differentially expressed genes (adjusted p<0.05) in keratinocytes (56 genes) and neutrophils (53 genes).

Acknowledgments

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