ZFIN Image: Aman et al., 2021, Fig. 4

Image

Figure Caption

Fig. 4 Dio2 is necessary for normal squamation pattern. (A) Loss of Dio2 function led to more numerous, smaller scales; similar to fish lacking thyroid glands. Visualized in sp7:EGFP transgenics (n ?= ?7, each genotype). (B) Similar to thyroid-ablated tg:Venus-NTR hypoTH fish, dio2 mutants began developing scales later, at a significantly larger standard length (SL; t12 ?= ?20.11, p ?< ?0.0001; n ?= ?7 each genotype). (C) Like thyroid-ablated hypoTH fish, change in timing and size at initiation of scale development was associated with an increased number of adult scales (t12 ?= ?19.84, p ?< ?0.0001). Bars in plots indicate means ?� ?95% CI. Scale bars, (A) 1 ?mm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 477, Aman, A.J., Kim, M., Saunders, L.M., Parichy, D.M., Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development, 205-218, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.