FIGURE 6

FIGURE 6

Differentiation stage (14 dpl) of brain regeneration and brain cancer share mechanisms related to developmental and morphogenetic processes. (A,B) Venn diagrams showing the number of upregulated (Up) or downregulated (Down) DEGs and the overlap between 14 dpl (purple) and (A) LGG (pink) and (B) GBM (blue). (C,D) Heatmaps showing the expression of genes shared between 14 dpl (purple), and (C) LGG (pink), and (D) GBM (blue). Each column represents a condition (14 dpl, LGG or GBM) and each row shows a single gene. The scale bar shows their log₂ fold changes from high to low regulation, represented by a color gradient from red to purple, respectively. (E,F) DAVID was used to show the most significantly enriched GO-BP (top 50), CC (top 5), and MF (top 5) terms based on transcriptional changes in comparison of 14 dpl with (E) LGG and (F) GBM by using human identifiers of shared DEGs. The heatmap scale shows log₁₀ of the ease p-values for the most significantly enriched GO terms. dpl: days post-lesion, DAVID: database for Annotation, Visualization and Integrated Discovery, GO: Gene Ontology, BP: Biological Process, MF: Molecular Function, CC: Cellular Component, dpl: days post lesion, LGG: low-grade glioma, GBM: glioblastoma.