FIGURE 4

FIGURE 4

Early wound healing stage (1 dpl) of brain regeneration is similar to brain cancer with respect to induction of metabolism- and neurogenesis-related signaling responses. (A, B) Venn diagrams showing the number of upregulated (Up) or downregulated (Down) DEGs and the overlap between 1 dpl (turquoise) and (A) LGG (pink) and (B) GBM (blue). (C, D) Heatmaps show the expression of genes shared between 1 dpl (turquoise) and (C) LGG (pink) and (D) GBM (blue). Each column represents a condition (1 dpl, LGG or GBM) and each row shows a single gene. The scale bar shows log₂ fold changes from high to low regulation, represented by a color gradient from red to purple, respectively. (E, F) DAVID was used to show the most significantly enriched GO-BP (top 50), CC (top 5), and MF (top 5) terms based on transcriptional changes in comparison of 1 dpl with (E) LGG and (F) GBM by using human identifiers of shared DEGs. The heatmap scale shows log₁₀ of the ease p-values for the most significantly enriched GO terms. dpl: days post-lesion, DAVID: database for Annotation, Visualization and Integrated Discovery, GO: Gene Ontology, BP: Biological Process, MF: Molecular Function, CC: Cellular Component, dpl: days post lesion, LGG: low-grade glioma, GBM: glioblastoma.