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FIGURE 3

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Publication: DiNapoli et al., 2022 - Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms
All Figures: Figures for DiNapoli et al., 2022

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FIGURE 3

A-366 induces inflammatory response with no effect on cellular growth. (A) Western blot of acid-extracted histones from A375 cells incubated with either DMSO or 0.2 µM A-366 for 48 h. Densitometry analysis from four independent experiments. (B) A375 cells were treated with the indicated concentrations of A-366 for 10 days and assessed for colony formation. (C) Cell growth analysis of A375 cells treated with DMSO or A-366 (n = 3). (D) Top 100 differentially expressed genes between DMSO and A-366 treated cells (sorted by p-value adjusted). (E) GSEA plot showing enrichment in A-366 treated cells. (F) RNA seq normalized counts for CD33 in sorted cells (n = 4). (p < 0.0001).

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