FIGURE 1

FIGURE 1

Structural domains of olfactorin and anosmin-1 and analysis of their N-terminal region. (A) The schematic comparison of the structures and of the main protein domains of anosmin-1 and olfactorin. (B) The ribbon representation of the domain solution structure model of human (green) and mouse (blue) olfactorins showing a similarity with human anosmin-1 (grey) in the N-terminal region of the molecules with common WAP (whey acidic protein-like) and FNIII (fibronectin type III) domains. (C) The ribbon representation and comparison of the WAP domains; the corresponding cysteine (C) residues forming disapplied bridges are evidenced. Abbreviations: EGF, calcium-binding EGF-like domain; FNIII, fibronectin type 3 domain; H, histidine-rich regions; SEA, sea urchin sperm protein; SP, signal; TM, transmembrane domain; WAP, whey acidic protein domain; ZP, zona pellucida domain.