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FIGURE 5
Effect of growth factor receptor inhibitors on olfactorinFLAG-induced GN11 chemomigration. GN11 cells were pretreated with FGFR1-3 inhibitor BGJ398 (10 and 50 µM) (A), VEGFR inhibitor AMG-706 (1 and 0.1 µM) (B), HGFR inhibitor SU11274 (10 and 50 µM) (C) and exposed to the control CM or olfactorinFLAG. The results (mean ± SD; n. 4) are expressed as the relative chemotactic response of GN11 cells with respect to the stimulus exerted by 0.1% FBS. *p < 0.05 vs. respective CM; **p < 0.05 vs. response to the CM of cells not pretreated with blockers.
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