ZFIN Image: Copmans et al., 2022, Figure 8

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Figure 8

Electrophysiological antiseizure analysis of plinabulin in the zebrafish EKP seizure model after a short- and long-term treatment. Anti-epileptiform activity of plinabulin after 2 h (A) and 18 h (B,C) in the zebrafish ethyl ketopentenoate (EKP) seizure model. Electrophysiological data is normalized against the vehicle (VHC) + VHC control condition and expressed as normalized power spectral density (PSD) (mean ± SEM) per larva within the 20–90 Hz region (A,B) and as normalized PSD (mean ± SEM) per larva per 10 Hz frequency band from 1–150 Hz (C). Number of replicates per test condition was n = 13–16. Statistical analysis: one-way ANOVA with Dunnett’s multiple comparison test (A,B), two-way ANOVA with Dunnett’s multiple comparison test (C), outliers were removed via the ROUT test (Q = 1%) (GraphPad Prism 9, San Diego, CA, USA). Significance levels: * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001.

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