ZFIN Image: Codolo et al., 2022, Figure 7

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Figure 7

The anti-tumor activity of HP-NAP is strictly dependent on macrophages: effect of macrophage depletion by L-Leucyl L-Leucine Methyl Esther (L-LME). Tg(mpeg1:EGFP)gl22 zebrafish embryos were xenotransplanted with M121224 melanoma cells (red) and treated with saline (vehicle), or L-leucine methyl ester (L-LME), L-LME + HP-NAP or HP-NAP at 2 dpi and observed at 4 dpi. (A) Representative fluorescence stereoscope images of the total tumor mass in fishes at 4 dpi. Scale bar, 1 mm. (B) Scatter plots show the quantification of the total tumor size (AU: Arbitrary Unit) at 4 dpi. Values are expressed as mean ± SEM and analyzed by one-way ANOVA; ****, p < 0.0001, HP-NAP vs. vehicle (n = 12 for each condition); ***, p < 0.01: L-LME + HP-NAP (n = 12) vs. HP-NAP (n = 12).

Acknowledgments

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