ZFIN Image: Codolo et al., 2022, Figure 6

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Figure 6

The anti-tumor activity of HP-NAP is strictly dependent on macrophages: effect of macrophage depletion by liposome-encapsulated clodronate (L-CLO). Tg(mpeg1:EGFP)gl22 zebrafish embryos were xenotransplanted with M121224 melanoma cells (red) and treated with empty liposomes + saline (vehicle), or empty liposomes + HP-NAP, L-CLO + saline (L-CLO) or L-CLO + HP-NAP at 2 dpi and observed at 4 dpi. (A) Representative fluorescence stereoscope images of the total tumor mass in fishes at 4 dpi. Scale bar: 1 mm. (B) Scatter plots show the quantification of the total tumor size (AU: Arbitrary Unit) at 4 dpi. Values are expressed as mean � SEM and analyzed by one-way ANOVA; ***, p < 0.001, HP-NAP (n = 9) vs. vehicle (n = 11) and L-CLO + HP-NAP (n = 9) vs. HP-NAP (n = 11).

Acknowledgments

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