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Figure 4 Effects of DHA on cell growth, cell apoptosis and cell cycle. (A) Growth of ZFL cells treated with DHA for 48 h. (B) Cell apoptosis and (C) cell cycle of ZFL treated with DHA at 24 h. (D) Relative mRNA expression of genes encoding D-type Cyclins in ZFL cells. (E) Relative mRNA expression of genes encoding D-type Cyclins in the liver of LFD, HFD, and HFDHA0.5-fed zebrafish. (F) Relative mRNA expression of genes encoding D-type Cyclins in ZFL cells treated with OA and ODHA. Values are means ± SEMs (n = 3-5 biological replicates). Means without a common letter are significantly different, P < 0.05. *P < 0.05.