ZFIN Image: Wang et al., 2021, Fig. 6

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Figure Caption

Fig. 6 MRE11 expression in oral cancer cells is associated with metastasis in zebrafish and mouse models.

A An example of oral cancer cell migration in zebrafish. B Quantitation of the effects of MRE11 knockdown and overexpression in oral cancer cells on migration in zebrafish model. C The effect of MRE11 overexpression in oral cancer cells on total flux of lung metastasis. D The effect of MRE11 overexpression in oral cancer cells on metastatic lung tumor area. E–H The effect of MRE11 overexpression in oral cancer cells on the expression of MRE11, RUNX2, CXCR4, and pAKT in metastatic lung tumor tissues. I CXCR4 neutralizing antibody reverse the cancer metastasis promoted by MRE11 overexpression in mouse model. Representative microscopic views of the lung sections. Hematoxylin-positive blue-colored nodules indicate metastatic colony number (Student’s t test) and tumor area (%) (Mann–Whitney U test). J Schematic diagram for MRE11 signaling pathway and activity.

Acknowledgments

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