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Fig. 5
MRE11 knockdown decreased orthotopic oral tumor growth and cervical lymph node (CLN) metastasis with decreased expression of CXCR4 and pAKT but increased expression of FOXA2 in oral cancer tissues.
A The effect of MRE11 knockdown in oral cancer cells on orthotopic oral tumor volume. B The effect of MRE11 knockdown in oral cancer cells on weekly total flux of orthotopic oral tumors. C The effect of MRE11 knockdown in oral cancer cells on total flux of orthotopic oral tumors at sacrifice. D–I The effect of MRE11 knockdown in oral cancer cells on the expression of MRE11, Ki67, RUNX2, CXCR4, pAKT, and FOXA2 in oral tumor tissues. J An example of CLN metastasis shown by IVIS imaging and H&E stain. K Quantitative data of CLN metastasis in mice when MRE11 expression in oral cancer cells was knockdowned.
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