ZFIN Image: Bu et al., 2021, Figure 6

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Figure Caption

Figure 6

Therapeutic effects of mtor inhibition on the VAC model.

(A and B) Representative Western blots showing the levels of proteins involved in mTOR signaling pathways in WT controls, vmhcl^e13/+, and vmhcl^e13/+mtor^xu015/+ mutants and quantification analysis. n = 3 biological replicates; data are presented as the mean ± SD; 1-way ANOVA. (C and D) Quantification of the percent EF and FS using echocardiography in fish at 8 months. n = 12; data are presented as the mean ± SD; 1-way ANOVA. (E and F) Representative images of isolated hearts and H&E staining in the apex area in fish at 8 months. (G and H) Quantification of the VSA normalized to BW and trabecular muscle density in these mutants and WT controls at 8 months. n = 6; data are presented as the mean ± SD; 1-way ANOVA. Scale bars: 2 mm in E and 300 μm in F.

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Acknowledgments

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