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Fig. 2 (A–C) Intestinal biomarkers for oxidative stress in 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 for 2 weeks, including (A) mitochondrial ROS, (B) MDA, and (C) PC. (D) Intestinal total antioxidant capability in 1-month-old zebrafish fed LFD, HFD, or HFSP0.5 for 2 weeks. (E–G) Intestinal antioxidant enzymes in 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 for 2 weeks, including (E) Sod2, (F) Gpx, and (G) Cat. (H) Representative histopathologic images of H&E-stained intestinal sections in zebrafish intraperitoneally injected with 4-hydroxy-TEMPO, a membrane-permeable radical scavenger. The scale bar, 50 μm. (I) Histological score measuring the severity of the intestinal damage of zebrafish intraperitoneally injected with 4-hydroxy-TEMPO. Values are means ± SEM (n = 5–12). Means without a common letter are significantly different (p < 0.05). Duncan's test.