ZFIN Image: Guan et al., 2021, Fig 7

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Figure Caption

Fig 7

RIC works through activation of nrf2a in zebrafish.

(A) Kaplan-Meier survival curve of zebrafish subjected to LPS treatment. nrf2a knockdown resulted in earlier mortality in response to LPS exposure (80 ?g/mL) and the protective effect of RIC Plasma was abolished in nrf2a knockdown zebrafish (n = 26?33). (B) RIC Plasma from Nrf2 KO mice did not exert survival benefit in response to LPS exposure (80 ?g/mL) induced mortality in zebrafish (n = 26?30). (C) Real time PCR showed the expression level of duox in the fish treated with the plasma in nrf2a-knockdown fish. *p<0.05. (D) Real time PCR showed the expression level of hmox1a in the fish treated with the plasma in nrf2a-knockdown fish. *p<0.05.

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