IMAGE

Figure 4

ID: ZDB-IMAGE-211120-52
Publication: Ding et al., 2021 - The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling
All Figures: Figures for Ding et al., 2021

Image

Figure Caption

Figure 4

Transcriptional disruption of genes related to erythrocyte function and homeostasis after smarca5 deletion.

(A) Schematic representation of the RBC RNA-seq workflow in smarca5^zko1049a and their siblings at 2 dpf. (B) Volcano plot showing differential expression genes between RBCs from smarca5^zko1049a and their siblings by DESeq2. −Log10 P, negative log10 adjusted p-value. Adjusted p-value < 0.05, log2 fold change >1. (C) Differential pathways enriched in RBCs from smarca5^zko1049a and their siblings by GSVA. The x axis represents the t values of GSVA scores. Two-sided unpaired limma-moderated t test. (D) Enrichment plots for the top pathways in the mutant RBCs by GSEA (Gene Set Enrichment Analysis).

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife