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Fig. 4 HS/heparin treatment can reduce the coagulation caused by S protein. (A, B) The effect of HS and heparin (Hep) co-injection with S trimer on bleeding time; ****, P < 0.0001. (C) The frequency (F) of thrombosis happened in capillaries (DLAV, ISV and CVP), large vessels including artery and vein (DA, PCV), and both capillaries and large vessels (DIC + DP).
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Reprinted from International journal of biological macromolecules, 193(Pt B), Zheng, Y., Zhao, J., Li, J., Guo, Z., Sheng, J., Ye, X., Jin, G., Wang, C., Chai, W., Yan, J., Liu, D., Liang, X., SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate, 1124-1129, Copyright (2021) with permission from Elsevier. Full text @ Int. J. Biol. Macromol.