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Fig. 3 SARS-CoV-2 S protein causes coagulation and thrombosis in zebrafish. (A, B) The positions and the timeline of microinjection and the mechanical injury on zebrafish embryos. (C) The effect of S trimer on bleeding time in response to the mechanical injury; ****, P < 0.0001. (D, E) Imaging analysis of o-dianisidine stained embryos microinjected with PBS and S trimer. (F, G) Confocal imaging analysis of Tg(gatal:DsRed:fli1a:Egfp-CAAX) embryos microinjected with PBS and S trimer.
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Reprinted from International journal of biological macromolecules, 193(Pt B), Zheng, Y., Zhao, J., Li, J., Guo, Z., Sheng, J., Ye, X., Jin, G., Wang, C., Chai, W., Yan, J., Liu, D., Liang, X., SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate, 1124-1129, Copyright (2021) with permission from Elsevier. Full text @ Int. J. Biol. Macromol.