ZFIN Image: Robinson et al., 2021, Figure 1

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Figure 1

Treatment with BLD-2736 from 1 to 6 days post-fertilization improves SCA3 zebrafish swimming performance. (A) Representative trajectories displaying the distance swum during motor performance assays at 6 days post-fertilization. (B) Transgenic zebrafish expressing EGFP-fused human ataxin-3 with 84 polyglutamines swim shorter distances than zebrafish expressing EGFP-fused human ataxin-3 with 23 polyglutamines. Treatment with calpain inhibitors (BLD-2736 or calpeptin) improved the distance swum. All data are presented as mean ± SEM, n = 12–24 larvae were examined per group. * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001.

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Acknowledgments

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