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Publication: Chen et al., 2021 - NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models
All Figures: Figures for Chen et al., 2021

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FIGURE 4

NS398 reduces cyst formation in vivo. (A) Representative images of Pkd2 morphants treated with vehicle (DMSO) or NS398. (B) Quantification showing the average percentage of embryos with kidney cysts in the two groups from three independent experiments. Fifty embryos per group were examined in each experiment. (C) and (D) Representative immunohistochemical images of kidneys and scans of whole kidneys isolated from Pkd1‐knockout mice treated with the vehicle (DMSO) or 20 μg/g NS398, stained with HE. (E), (F), and (G) Quantitative analysis of kidney/body weight ratio, CI, and BUN levels of wild‐type, diseased and NS398‐treated mice (n = 5 per group; p < 0.05.) (H) Western blot showing the effects of NS398 on the levels of phospho‐ and total Akt and ERK in diseased and NS398‐treated mice (*p < 0.05, t test)

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