IMAGE

Figure 2

ID

ZDB-IMAGE-211025-21

Antibodies

Ab13-hspa5

Publication

Cairns et al., 2021 - A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay

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Figures for Cairns et al., 2021

Image

Figure Caption

Figure 2

Effects of the unfolded protein response in wfs1a^−/− and wfs1b^−/− zebrafish. Treated zebrafish were heat shocked for 1 h at 6 hpf (groups of 50 embryos). (A) Representative images of the morphological effects for each genotype at 80 hpf. Scale bar = 1 mm. (B) Percentage of dead zebrafish at 24 hpf. Data plots represent mean ± SEM (n = 5 groups of 50). Statistical significance was determined by One-Way ANOVA with Bonferroni multiple comparisons. (C) Immunoblot of BiP in untreated and heat shocked zebrafish showing an upregulation of BiP in response to heat shock. Coomassie staining demonstrates equal loading. *p < 0.05; **p < 0.01; ****p < 0.0001; h/s: heat shock treated.

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Acknowledgments

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