ZFIN Image: Tanoue et al., 2021, Figure 5

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Figure 5

The protein expressions of Nphs2, Podxl, and Nphs1 and the number of Wt1 positive cells in the glomeruli were decreased in podocyte-specific Crb2 knockout mice. (a) An immunofluorescence study showed that Nphs2, Podxl, and Nphs1 expression significantly decreased in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^fl/fl mice. Scale bars 50 μm. (b) The protein expressions of Nphs2, Podxl, and Nphs1 were significantly decreased in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^fl/fl mice. (c) Wt1-positive cells were significantly decreased in the glomeruli of Crb2^fl/flpod-Cre^Tg/+ mice compared to those of Crb2^fl/fl mice. Data are presented as mean ± SD. Statistical analysis by Student's t-test; n = 5 in each group. *P < 0.05, **P < 0.01, ****P < 0.0001.

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