ZFIN Image: Tanoue et al., 2021, Figure 3

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Figure 3

Podocyte-specific Crb2 knockout mice develop FSGS at 6 months of age. (a) Massive albuminuria was observed at 6 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Microhematuria was observed at 6 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. (b) The blood urea nitrogen and serum creatinine levels were comparable among the three groups at 6 months of age. (c) The sclerotic indices in Crb2^fl/flpod-Cre^Tg/+ mice were significantly higher than those in Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Scale bars 50 μm. (d) The fibrotic indices in Crb2^fl/flpod-Cre^Tg/+ mice were significantly higher than those in Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Scale bars 100 μm. Data are presented as mean ± SD. Statistical analysis by one-way analysis of variance, followed by Scheffe's multiple comparison test; n = 6 in each group. ***P < 0.001, ****P < 0.0001.

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