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Publication: Ruggiero et al., 2021 - Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions
All Figures: Figures for Ruggiero et al., 2021

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FIGURE 1

Above: Establishment of a TALEN-mediated per2 KO zebrafish line. A pair of TALENs was used to target the 2nd exon of the zebrafish per2 gene (TALEN left and right target sites are highlighted in yellow). A deletion of 8 bp (red dashes against a gray background) resulted in a frameshift mutation. Below: The consequent introduction of a premature stop codon and a predicted truncated PER2 protein of 160 aa compared with the 1399 aa WT protein. PER-ARNT-SIM domains (PAS, orange) and C-terminal of PAS domain (PAC, green) in the WT protein are indicated.

Acknowledgments

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