ZFIN Image: Berlingerio et al., 2021, Figure 3

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Figure Caption

Figure 3

Kidney cystine crystals in wild-type and ctns^−/− zebrafish PTECs. (A,B) Representative toluidine blue-stained images of renal proximal tubules in wild-type (A) and ctns^−/− (B) 18-month-old zebrafish. The scale bars represent 50 µm. (C,D) Figure 3C,D show a higher magnification of Figure 3A,B. Details of renal proximal tubules with cytoplasmic vacuoles ((D); *), rectangular and polymorphous vacuolar spaces ((D); black arrowheads). (E,F) Representative TEM images of the renal proximal tubule of wild-type (E) and ctns^−/− 18-month-old zebrafish (F). (F) Partial loss of proximal tubule brush borders (PB) and accumulation of the rectangular and polymorphous vacuoles (*) were observed in the renal proximal tubule of ctns^−/− zebrafish. The high-magnification view of the rectangle in the bottom right corner shows the polymorphous vacuoles and a large vacuole with straight membrane border segments (a straight line). The scale bars represent 5 µm.

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Phenotype details

Acknowledgments

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