Figure 4.

Figure 4.

kif2a^−/− larvae show increased susceptibility to epilepsy. a, Visual representation of the setup of local field potential recording from optic tectum (indicated in red) of 5 dpf larvae. b, Number of seizures and average seizure duration in kif2a^+/+ and kif2a^−/− larvae. c, Number of seizures and average seizure duration in kif2a^+/+ and kif2a^−/− larvae after 6 mm PTZ immersion for 15 min. d, Representative fragments of a 10 min recording (calibration: 0.1 mV, 20 s) of kif2a^+/+ and kif2a^−/− larvae after 6 mm PTZ immersion for 15 min, with enlargement of a polyspiking event (calibration: 0.02 mV, 2 s) in kif2a^−/− larvae. Data are represented as the mean ± SD. Significant values are noted as **p ≤ 0.01. No increased seizure susceptibility was observed in the brains of kif2a^−/− zebrafish larvae from +/– incrosses (Extended Data Fig. 4-1).