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Publication: Watterston et al., 2021 - Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting
All Figures: Figures for Watterston et al., 2021

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Fig 5 Model of <italic toggle='yes'>sema3fb</italic> action in sprouting vessels.

Sema3fb is expressed by endothelial cells during angiogenic sprout formation and acts through an autocrine mechanism to suppress Vegfr2 expression and maintain endothelial cell dynamics via controlling Dll4 expression and Notch signaling in addition to modulation of pERK. Loss of sema3fb increases Vegfr2, pERK, Dll4, and sFlt1 expression. This results in aberrant cellular morphology with wider sprouts, persistent filopodia, and larger nuclei. The changes in nuclear size and disrupted sprouting suggest a possible role for Sema3b to limit Vegf-mediated induction of downstream pERK signaling.

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