ZFIN Image: Lu et al., 2021, Figure 2

Image

Figure Caption

Figure 2

Synergistic effect of kras^V¹² expression and LPS treatment in intestinal tumorigenesis. Four-month-postfertilization WT and kras+ zebrafish were cotreated with 2 ?M of mifepristone and 40 ng/mL of LPS for 4 weeks, and samples were then collected for gross observations and histological analyses. There were four experimental groups: WT, WT/LPS, kras+, and kras+/LPS. (A,B) Body length and body weight. (C) Survival curves. (D) Examples of normal intestines, enteritis, hyperplasia, and tubular adenoma as revealed by H&E-stained sections of the intestine. (E) Summary of intestinal histological abnormalities observed in the four experimental groups. These data were generated from results of a blinded histological analysis (WT, N = 20; WT/LPS, N = 20; kras+, N = 20; kras+/LPS, N = 20). Differences among the variables were assessed using Student?s t-tests or one-way ANOVA. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001. Scale bar: 50 ?m.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomedicines