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FIGURE 5

ID: ZDB-IMAGE-210902-29
Publication: Koh et al., 2021 - Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy
All Figures: Figures for Koh et al., 2021

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FIGURE 5

Summary of FCS observations. (A) Freely diffusing mCherry. (B) Two components of freely diffusing mCherry-Smn and mCherry-Smn with endogenous Smn in complexes that are distinct for cell body and axon (oligomers of mCherry-Smn and Smn are indicated by tetramers). (C) Truncated eGFP-Smn concentrates in nucleus, freely diffuses in cytoplasm. Complexes consist of only endogenous Smn. (D) Depletion of endogenous Smn led to a depletion of freely diffusing mCherry-Smn and mCherry-Smn replacing endogenous Smn in complexes. For details, see main text.

Acknowledgments

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