ZFIN Image: Kuil et al., 2021, Fig 4

Image

Figure Caption

Fig 4 Validation of tbx2, ufd1l and mapk8 gene disruption shows effects on the ENS in zebrafish.

(A) Figures and graphs showing that disruption of tbx2a/b in zebrafish does not result in overall significantly reduced numbers of phox2bb-GFP+ cells, however it does induce ENS phenotypes in category II and III in a significant number of zebrafish larvae. (B) Figures and graphs showing that disruption of ufd1l in zebrafish results in significantly reduced numbers of phox2bb-GFP+ cells and increase in the percentage of fish presenting with an ENS phenotype. (C) Figures and graphs showing that disruption of mapk8a/b in zebrafish does not result in overall significantly reduced numbers of phox2bb-GFP+ cells, however it does induce ENS phenotypes in a significant number of zebrafish larvae. Statistical tests used: students t-test and "N-1" Chi-squared test; * p < 0.05 ** p < 0.01 *** p < 0.001; Exact p-values and statistics can be found in S11 Table.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.