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Fig. EV2

ID: ZDB-IMAGE-210817-23
Publication: Sehgal et al., 2021 - LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy
All Figures: Figures for Sehgal et al., 2021

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Figure Caption

Fig. EV2 Representation of the site of interaction of <italic toggle='yes'>veal2</italic> with the Prkcbb protein

A, B

Representation of interaction of veal2 WT RNA with Prkcbb protein. (B) Enlarged view of interaction of motif‐3 of veal2 and Prkcbb protein.

The 3 bases of motif‐3 (CLM) in veal2 are highlighted in pink, and the base positions are mentioned. The 4 amino acids known to bind with DAG (Leonard et al, 2011) within C1 domain of Prkcbb have been highlighted.

Relative kinase activity of human PRKCB2 under standard conditions and in the presence of various variants of veal2 lacking putative functional motifs and wt veal2 IVT RNA. Data from three different experiments plotted as individual values; the middle bar represents the mean, and the error bar represents ± standard deviation.

Data information: All the experiments N ≥ 3. ****P‐value < 1E‐4. Statistics: one‐way ANOVA with Bonferroni’s multiple data comparison

Acknowledgments

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