Fig 6

Fig 6

(A) Comparison of mGluR-dependent long-term depression (LTD) in CA3-CA1 components of the hippocampus of eight Fmr1^CRE male mice and eight wild-type male littermates indicates a significant Fmr1^CRE-associated decrease in LTD. (B) All quantitative data are presented as mean ±SE and p value of 0.05 or less is considered statistically significant.(C) No significant difference was observed in audiogenic seizure incidence in the hemizygous mice with the variant Fmr1^CRE(1/21) compared to wild-type littermates(3/9). Statistical significance is determined using two-tailed Fisher’s exact test and p value of 0.05 or less is considered statistically significant.(D) Significant increase in bulk protein synthesis levels in slices from dorsal hippocampus of Fmr1^CRE knock-in mutant male mice as compared to wild-type male littermates. Quantitative data is derived from number of biological replicates used (n = 6) in the experiments. Levels of significance were determined by 2-tailed Student’s t-test, with p values lower than 0.05 considered statistically significant. (* means difference is statistically significant).