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Figure 7

ID: ZDB-IMAGE-210813-12
Publication: Park et al., 2021 - Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly
All Figures: Figures for Park et al., 2021

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Figure Caption

Figure 7

Knockdown of ep300a and plaub caused the vascular occlusion phenotype in zebrafish. Lateral views of the trunk of Tg(gata1:dsred) zebrafish larvae (dorsal or ‘to the top’ and anterior or ‘to the left’) at 3 days post-fertilization (dpf) (A–D). Arrowheads indicate the slowly circulating red blood cells (RBCs) in the intersegmental vessels (ISVs). The bracketed area indicates stalled RBCs in the ISVs. Analysis of RBC circulation (E) in the control, ep300a, and plaub morpholino (MO)-injected larvae at 3 dpf (Control MO: 41.39 ± 2.39 (n = 23), ep300a MO: 31.97 ± 2.78 (n = 22), plaub MO: 18.79 ± 1.68 (n = 19), ep300a/plaub MO: 9.50 ± 2.01 (n = 16); *p < 0.05, ****p < 0.0001; scale bar = 100 µm).

Figure Data

Phenotype details

Acknowledgments

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