IMAGE

Fig. 6

ID

ZDB-IMAGE-210804-19

Genes

bmi1a
cbx4

Publication

Fang et al., 2021 - Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

All Figures

Figures for Fang et al., 2021

Image

Figure Caption

Fig. 6 Expression of neutrophil and PRC1 markers decreased with <italic>asxl1</italic> mutation.

A Heat map of differentially expressed genes (false discovery rate < 0.05; exact test) in 3 dpf asxl1^−/− compared to asxl1^+/+ via RNA-seq. Neutrophil markers (green), PRC1 members (orange), and inflammatory response associated genes (purple) were highlighted. Rep replicate. B Gene ontology (GO) enrichment analysis of biological processes based on differentially expressed genes identified through RNA-seq (hypergeometric test). C Expression of bmi1a and cbx4 from RNA-seq (n = 20 per replicate, CPM count-per-million; exact test, *false discovery rate (FDR) < 0.05, **FDR < 0.01, ***FDR < 0.001; error bars, mean ± SD). qRT-PCR comparing expression of bmi1a and cbx4 in asxl1^+/+ and asxl1^−/− in 3 dpf larvae (n ≥ 10 per group, performed with four replicates; two-tailed Student’s t test, *p < 0.05, **p < 0.01, ***p < 0.001; error bars, mean ± SD) (color figure online).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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