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Wen et al., 2021 - The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics

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Fig 3 Transcription factor <italic toggle='yes'>klf6a</italic> regulates CV pruning in zebrafish.

(A) Generation of KI (klf6a -HA-P2A-gal4) fish. (B) Expression pattern of KI(klf6a-HA-P2A-gal4) fish. Arrowheads indicate the location of klf6a at the vasculature. (C) Role of klf6a in CV pruning in zebrafish embryos. Boxes show enlarged images of the CV. The arrowhead indicates the unpruned vessel. Scale bar: 50 μm. (D) Quantification of vascular loops in the sibling and klf6a^-/-: sibling, n = 23 embryos; klf6a^-/-, n = 13 embryos. P < 0.001. Student’s unpaired two-tailed t test.

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