ZFIN Image: Hsiao et al., 2021, FIGURE 7

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FIGURE 7

Effects of altering mthfd1L expression on eye development in folate-deficient embryos. (A) FD mthfd1L morphants had their eye size measured at 3 dpf. (B) FD embryos were injected with 0–250 pg zebrafish mthfd1L cRNA and their eye size was measured at 3 dpf. (C)mthfd1L-cRNA-injected control and FD embryos had their OMR estimated at 7 dpf. (D–F) 30 hpf control and FD embryos with or without 250 pg mthfd1L cRNA injection were subjected to HPLC analysis for their content of 10-CHO-THF (D), 5-CH₃-THF (E), and THF/5,10-CH₂-THF (F). Ctl, control; mFD, mild folate deficiency; sFD, severe folate deficiency; *p < 0.05; **p < 0.01; ***p < 0.001.

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Acknowledgments

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