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Publication: Hsiao et al., 2021 - The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects
All Figures: Figures for Hsiao et al., 2021

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FIGURE 4

Larval folate composition and response to rescuing agents. Both control and FD embryos continuously exposed to rescuing agents starting from 25 hpf were examined for their intracellular folate composition (A) at indicated stages with HPLC as described in materials and methods, eye size (B–F) at 3 dpf and OMR (G) at 7 dpf. The rescuing agents include deoxy-ribonucleoside triphosphate (dNTP) (B), Deoxythymidine triphosphate (dTTP) (C), hypoxanthine (Hx) (D), formate (NaF, sodium formate) (E) and N-acetyl-cysteine (NAC) (F). Statistical results are shown in mean ± SEM for (B–F) and percentage in a group for (G). ***p < 0.001; **p < 0.01; *p < 0.05.

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