IMAGE

D–J

ID: ZDB-IMAGE-210714-45
Publication: Jamalpoor et al., 2021 - Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
All Figures: Figures for Jamalpoor et al., 2021

Image

Figure Caption

D–J Toxicity profile of dimethyl α‐ketoglutarate (DMKG) and the drugs tested for the treatment of cystinosis

Cell viability curves of dimethyl α‐ketoglutarate (DMKG) in CTNS^WT and CTNS^−/− cells after 4 h of incubation in fed and starved condition (n = 3).

B, C

Cell viability curves of the increasing concentration of DMKG in control (CTNS^WT) and CRISPR‐generated cystinotic (CTNS^−/−) cells after 24 h of incubation in fed and starved condition, respectively (n = 3).

D–J

Cell viability test in CTNS^WT, CTNS^−/− cells treated with the increasing concentrations of cysteamine, bicalutamide, luteolin, genistein, 8‐bromo‐cAMP, disulfiram, and a combination of cysteamine and bicalutamide (100 and 35 µM, respectively), respectively (n = 3).

Data information: Data are expressed as mean ± SEM.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.