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Figure 3 BMP and Notch signaling pathways differentially influence ventricle regeneration and cardiogenic factor re-activation. (A, B) Quantification of heart recovery rate in control and DAPT-treated or DM-treated ablated hearts at 4 dpt. The numbers of larvae analyzed were indicated. Binomial test, n.s, non-significant, *, P < 0.05, **, P <0.01, ***, P < 0.001. (C-T) Whole-mount in situ hybridizations showed different effects on the re-activation of cardiogenic factor nkx2.5 (C-H), gata4 (I-N), tbx20 (O-T) after DAPT or DM treatment at 5 dpf/2 dpt. Scale bar, 50 µm. dpf, days post fertilization; dpt, days post MTZ-treatment; A, atrium; V, ventricle; Ctrl, control; DM, dorsomorphin. Dashed lines outline the hearts.