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Figure 6

ID: ZDB-IMAGE-210708-61
Publication: Salam et al., 2021 - Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations
All Figures: Figures for Salam et al., 2021

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Figure 6

Expression of mutant FUS leads to mitochondrial abnormalities. (A) Representative confocal images of rat primary neurons co-transfected with eGFP, eGFP-FUS^WT, eGFP-FUS^R514G or eGFP-FUS^ΔNLS (green) and Ds-MitoRed (red). Boxes show a region of interest that was used for quantification and magnified underneath. Scale bar = 10 μm. (B,C) Quantitative analysis of the average number and area of mitochondria within each dendritic branch after co-transfection with Ds-MitoRed and WT and mutant FUS. Statistical analysis was performed using a One-Way ANOVA with a post-hoc Tukey’s multiple comparisons test. n = three neurites from five different cells from three independent replicates were analysed for each co-transfection.

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