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Figure 6

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Publication: Buchberger et al., 2021 - A novel inhibitor rescues cerebellar defects in a zebrafish model of Down Syndrome-associated kinase Dyrk1A overexpression
All Figures: Figures for Buchberger et al., 2021

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Figure 6

Novel tank diving test reveals anxiety-like behavior in adult Tg(Car8-hDryk1A-mClover) fish.A–F, swimming behavior of adult WT (n = 14) and PC-Dyrk1A fish (n = 10) examined in the novel tank diving test. The number of zone transitions (A, two-tailed unpaired t test, p = 0.003), the time in the top part (B, nonparametric t test, p = 0.0015), the distance covered (C, two-tailed unpaired t test, p < 0.0001), and the speed (D, two-tailed unpaired t test, p < 0.0001) were determined in 6-min recordings. All parameters analyzed were significantly reduced in PC-Dyrk1A fish. E and F, representative tracks of a control (E) and PC-Dyrk1A zebrafish with bottom (light blue) and top part (light gray) of the tank. Means ± SD. The scale bar represents 3 cm. Dyrk1A, dual-specificity tyrosine phosphorylation–regulated kinase 1A; PCs, Purkinje cells. ∗∗p < 0.01, ∗∗∗∗p < 0.0001.

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