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FIGURE 4

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Publication: Gourain et al., 2021 - Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury
All Figures: Figures for Gourain et al., 2021

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FIGURE 4

Sterol Regulatory Element (SRE) motif analysis. (A) Two mammalian SRE motifs were retrieved from the literature (left and middle panels). From the mapping of these two consensus sequences one SRE motif derived in the zebrafish genome (right panel). (B) The SRE motifs were mapped in the promoter of genes involved in cholesterol metabolism. The promoter sequence was defined from 1 kb upstream of the transcription start site and the SRE motif were mapped in both forward (+) and reverse (–) strands. (C) Genes harboring a SRE motif in their 1-kb promoter (underlined) were identified in the cholesterol synthesis pathway, including genes coding for two upstream regulators (srebf2 and insig1). For further details see also legend to Figure 3A.

Acknowledgments

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