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Publication: Gourain et al., 2021 - Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury
All Figures: Figures for Gourain et al., 2021

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FIGURE 3

Alteration in cholesterol metabolism in response to brain injury. (A) Increases in level of transcripts coding for cholesterol synthesizing enzymes (green) and decreased level of transcripts coding for transporter involved in ferrying cholesterol through the body and across membrane (red) were identified. Products and substrates are represented in blue boxes and enzymatic reactions by blue arrows. The double black arrow represents flow across membrane. (B,C) Changes in levels of mRNA were validated comparing the quantification by qRT-PCR of mRNAs encoding three selected enzymes synthesizing cholesterol (B) and two transporters (C) in three independent control (yellow) and injured (blue) telencephalic hemispheres (n = 3). *p-value = 0.05, **p-value < 10^{– 03}.

Acknowledgments

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