ZFIN Image: Tseng et al., 2021, Fig. 8

Image

Figure Caption

Fig. 8 (A) Live imaging of 30?hpf wild-type embryos treated with the indicated dose of U18666A starting at 4?hpf. U18666A-treated embryos exhibited a dose-dependent phenotype ranging from smaller otoliths at 24??M to no otoliths, abnormal head, no circulating blood cells, and curved/twisted body axis at 96??M. Arrowheads indicate the otic vesicle. Scale bars: 500??m (whole embryo); 200??m (otic vesicle). (B) Measurement of otolith diameters from DMSO- and U18666A-treated wild-type embryos at 30?hpf. n=118 (DMSO), 118 (24??M), 114 (48??M) and 94 (96??M) (n=2 experiments). Two otoliths per embryo were measured. 0 indicates that otolith was not detectable. P<0.0001 for each treatment group compared with DMSO (Kruskal?Wallis test).

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development