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Figure Caption
Figure 1 Organization of the human and zebrafish MAPT genes. Human MAPT gene is represented with the major isoforms used in transgenic models and found in patients, 2N4R, 0N4R, and 0N3R. Orange exons encode N-terminal domain and green exons encode repeats domain (R) that belong to microtubule binding domains. Exon 10 is alternatively spliced to generate 3R isoform. Zebrafish mapta and maptb genes have 13 exons each (blue), with green exons encoding microtubule binding domains, and yellow one labelling alternatively spliced exons.
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Full text @ Int. J. Mol. Sci.