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Publication: Knickmeyer et al., 2021 - BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish
All Figures: Figures for Knickmeyer et al., 2021

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Figure 2 Ubiquitous bmp4 induction, but not eye specific bmp4 expression, results in a midline defect. (A–C) Immunohistochemistry against GFP in (B,C) tg(pou4f3:mGFP, rx2:bmp4) embryos and (A) controls at 4 dpf. Chiasms are intact, but optic nerve trajectories are irregular (arrows). (D–K) Immunohistochemistry against Ac-αTub and GFAP in (E,G,I,K) tg(hsp70l:bmp4) embryos and (D,F,H,J) controls at 25–45 hpf reveals the anterior (asterisks) and post-optic (arrowheads) commissures. Later stages include optic nerves (arrows). All images are maximum intensity projections, transverse view, scale bars 50 µm.

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