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Fig. 10 Proposed model of fate of S. aureus within neutrophils. Staphylococci are internalized by neutrophils and trapped within LC3-associated phagosomes (LAPosomes) triggered by NADPH oxidase. LAPosomes do not get acidified and provide a replication niche for internalized S. aureus, which eventually will damage the phagosomal membrane and escape into the cytoplasm. This is sensed by Sqstm1/p62 – a member of the selective autophagy machinery, which could lead to the formation of autophagosomes containing staphylococci and leading to pathogen inactivation
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