Fig. 6

Fig. 6

Exosome‐mediated drug resistance transmission in MCF‐7 cell‐formed tumors in zebrafish. (A) PKH26‐labeled MCF‐7 cells were incubated with S/sEVs, A/sEVs, and TGF‐β1 silenced A/sEVs. The exosome‐internalized cells were injected into zebrafish embryos. The hatched fishes were grown with 50 µm adriamycin or left the drug as a negative control. The formed tumors in the fish bodies were screened as indicated. (B) The tumor volumes were calculated and plotted. 10–15 fishes were grown in each experimental group, and the data were presented as the mean ± standard deviation. *P < 0.05 and **P < 0.01 represent the significances between two groups as indicated.