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Fig. 13 Structures and properties of the Diversity Set hits. Table illustrating structures and properties of the 8 compounds from the Life Chemicals Diversity Set that protect mouse OHCs from exposure to gentamicin in vitro. Names of compounds in the first column are colored according to dendrogram group shown in Figure 1. The molecules and their substructure classification are based on a working model that assumes likely commonality in the mode of binding to the channel. Properties shown are molecular weight (MW), lipophilicity (cLogP and cLogD), calculated acid dissociation constant (pKa), and fractional (%) block of MET current by 50 μM of compound at a holding potential of –164 mV. The basic N is indicated with an asterisk. Moieties outlined are piperidine (blue), piperazine (green), benzimidazole (red), metachlorophenyl, pyridine (orange for UoS-5247 and UoS-962, respectively), and furan (purple). Lipophilic aromatic moiety for UoS-7692, UoS-8052, UoS-3607, UoS-3606, UoS-962, and UoS-9645 is outlined in magenta and lipophilic side chain of UoS-5247 is outlined in maroon.